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KMID : 0380620170490060676
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Korean Journal of Food Science and Technology
2017 Volume.49 No. 6 p.676 ~ p.684
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Antihepatotoxic effect of ethanol extracts from steam-dried ginseng berry on D-galactosamine/lipopolysaccharide-sensitized mice
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Jang Su-Kil
Park Jun-Sub
Ahn Jeong-Won
Jo Bo-Ram
Kim Hyun-Soo
Kim Jeong-Hoon
Kim Sang-Yun
Park Jung-Youl
Lee Do-Ik
Park Hee-Yong
Joo Seong-Soo
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Abstract
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The present study aimed to examine the hepatoprotective effects of ethanol extracts from steam-dried ginseng berry (SGBE) in both D-Galactosamine/Lipopolysaccharide (D-GalN/LPS)-sensitized mice and in vitro models. Our results clearly demonstrated that SGBE significantly reduced the level of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase in blood, and TNFα was normalized in 8 h after the treatment with D-GalN/LPS. Coincidently, major organs remained unimpaired when compared to D-GalN/LPS control group. Moreover, p38, which stimulates expression of NAFLD-associated cytokines, was markedly inhibited when treated with SGBE. In vitro analysis revealed that the main components of SGBE, linoleic acid and ginsenoside Re/Rd, may play a role in protecting liver from D-GalN/LPS-induced toxicity. Finally, we concluded that SGBE may be a promising therapeutic agent for preventing damage to the liver.
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KEYWORD
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ginseng berry, D-galactosamine/lipopolysaccharide, non-alcoholic fatty liver disease, ginsenoside, linoleic acid
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